Contac CoughCaps are a very good source of DM, they contain nothing bbut 30mg DM in each cap. Working dosage for me (6'1" 210-220 lbs) has been 900mg DM or 30 tablets. This might be far more than you will need, I suggest determining how much Robotussin you would normally take in oreder to achieve the desired effects and convert across (100ml Robo==300mg DM==10 CoughCaps). Once you have figured out your dosage it is best to take the tablets over the course of an hou. You do not want them to clump up and dissolve slowly in one place, In fact it might even be better to take them with some food. Just be careful with alcohol intake during this time, while it is true that your alcohol levels will effect the intensity and depth of the stone (the more alcohol in your system the higher you get {tres' synergistic}) higher lavels of alcohol can also make you feel naseaus to the point of vomiting (mind you this dosn't last all that long, but it is unpleasent [as is any vomiting on psychedelics]) Smoking a joint or three will also have a synergistic effect, as will eating mushrooms or chewing morning glory seeds (haven't found any acid in years :( ). ahaigh@unixg.ubc.ca ============================================================================= This is what I have found, your mileage will vary according to what else you are taking at the time. 300mg DM == light buzz, similiar to 50-100yg lsd 600mg DM == stronger, similiar to 100-250ug lsd 900mg DM == very strong, full spectrum of hallucinations equvalent to 300-600yg lsd These levels will have different effects on different people, and at different times for the same person, depending on what other drugs you are taking at the time. Personally I combine 900mg DM with alcohol, marijuana, and morning glory seeds. This I don't recommend for everyone, especially people unexperienced with psychedelics. Start off low and work your way up. And be careful, too much DM as well as too much alcohl at the same time will make you barf. ahaigh@unixg.ubc.ca ============================================================================= Okay, for anyone who wants to play around with dextromethorphan, this might be of use to you. Maybe an FAQ is needed? First, the biochemical side of things. Dextromethorphan acts as a cough suppressant via its agonist (activating) activity at mu-opioid receptors. Unlike codeine, it does not seem to activate other opioid receptors, except for the sigma receptor (see below). As far as its "other" effects, DXM is in the same class as ketamine, PCP, MK-801, and several other NMDA open channel blockers / sigma opioid ligands. The sigma opioid receptor's function is unknown but it may be implicated in schizophrenia. Sigma opioid agonists produce both the positive and the negative symptoms of schizophrenia, unlike dopaminergics which produce only the positive symptoms. The NMDA receptor is a fast ion-channel receptor which is normally activated by the excitory amino acids and possibly potentiated by glycine. There is a second NMDA receptor subtype in the cerebellum (this may account for DXM's perceived effect on motion). NMDA receptors probably exist in several different subtypes. DXM, ketamine, PCP, and other similar chemicals act as "open channel blockers." Upon the opening of the NMDA channel, the chemicals enter the channel and block ion transfer. DXM is a non-competitive blocker. In addition to this, there is a second "PCP2" binding site (the PCP1 site is the NMDA open channel block site). This may be a biogenic amine reuptake complex. If so, then these class of chemicals may act as reuptake inhibitors. The role of the PCP2 site is poorly understood. I don't know offhand the binding of DXM to sigma, PCP1, and PCP2 in comparison to ketamine, MK-801, and PCP. All of these drugs are being studied for their effects in preventing damage to the brain during siezure. In terms of effects on humans, described effects include dissociative anaesthesia, mild hallucinations, enhanced response to music (including highly pleasurable responses), and disturbances in motion. Nausea can occur. DXM has some stimulant effects. In terms of sources, DXM is available over-the-counter in many countries in tablet form. Robitussin Maximum Strength Cough (not Robitussin DM) contains DXM with nothing else (except a little alcohol). Robitussin DM also contains an expectorant which should not be taken in high doses. Dose of Robitussin Maximum Strength Cough is two to five full "shots" using the shot glass that comes with the bottle. The usual warnings apply. Additionally, prolonged use of DXM can and has led to psychosis similar to PCP-induced psychosis. Individual differences in NMDA receptors may be at work here, but you're still potentially at risk. I personally wouldn't mix DXM with anything. -- | Bill White +1-614-594-3434 | bwhite@oucsace.cs.ohiou.edu | | 31 Curran Dr., Athens OH 45701 | bwhite@bigbird.cs.ohiou.edu (alternate) | | SCA: Erasmus Marwick, Dernehealde Pursuivant, Dernehealde, Middle Kingdom | ============================================================================= From: Nathan.Bowen@mixcom.mixcom.com (Nathan.Bowen) Newsgroups: alt.drugs Subject: Re: Robitussin Message-ID: <1993Apr13.170256.10562@mixcom.com> Date: 13 Apr 93 17:02:56 GMT In jroberts@ux4.cso.uiuc.edu (jroberts@ux4) writes: >This may seem like a question that has been dragged through the mud, but >actually I have not seen too much information on Robitussin. When it is >mentioned, it is not made clear exactly what type of trip it gives, just that >it gives a trip. Is it hallucinogenic? Euphoric? Alcohol-like? How long >does it last? Any side effects? And what ever came of the evaporating >everything but the Dextromethorphan? What is the usual dosage (6-8 oz.'s?)? >Well, any responses would be appreciated. The trip is more of a buzz to my experience, and to that of my friends. I have been told that high dosages produce hallucinogenic effects similar to 'shrooms and LSD. I cannot deny this, because my highest dosage was 360, and most people who use it regularly have done 240 to the best of my knowledge. The usual dosage, then, is nonexistant - everyone has their own idea of how much is enough. Anything less than 240 will probably not do much more than make you a bit dizzy, groggy, and tired. 240mg would be a 4 ounce bottle of Robitussin-DM, but I would recommend avoiding this, because of the Guaifenesin it contains. You may want to go straight to 360mg, which is found in most "Maximum Strength" cough medicines, such as a certain formula of Vicks and Robitussin Maximum Strength. These also contain no guaifenesin, but usually do contain alcohol. If you can get to Canada, or have friends there who can mail things to you, you may want to consider Contac CoughCaps. They are, to my knowledge, little pills containing nothing but 30mg of DM HBr that are sold just about everywhere - with the exception of the USA. The experiences are quite unlike other mild drugs at the mild dosages. No one has recently reported here any visual hallucinations at the standard 4oz maximum strength cough syrup 360mg DM doses. On the other hand, most of us agree that our thought patterns are shifted noticeably, and there is a distinct difference to the sounds of music. Another effect that has been confirmed by several people , is the sensation that you're slurring your speech. I have actually carried on conversations with people while on heavy DM buzzes, and felt that I was slurring my speech uncontrollably, but I've been told that, in fact, the only thing that might have given me away was the "Pleasant Tasting Syrup" on my breath. Speaking for myself, I've noticed some really neat balance sensations/time distortions. A friend of mine who was kind of hanging out around my house while I was buzzing on DM suggested that I jump up and down. He's always been rather drug-free, and I wasn't preapred to take such a silly suggestion without some experience to back it up, but I finally gave in. It was great, and I kept it up for a few minutes. It's hard to explain, but I found that I landed a few seconds after I hit the ground. I also took a ball-like object and tossed it into the air to myself repeatedly. It, too, took its time about landing. Kind of novel, really. I have a collection of relevant articles on Robitussin/DM use around here somewhere, I'll clean it up and post it this week. -Nathan nathan.bowen@mixcom.com ============================================================================= From: pearl@crl.com (Peter Helyar) Newsgroups: alt.drugs Subject: Re: Tussin can be BAD! Date: 27 Sep 1993 19:33:24 -0700 Message-ID: <2887pk$d71@crl.crl.com> In article <2884sg$jjf@news.u.washington.edu> lamontg@cs.washington.edu writes: >jane@unislc.slc.unisys.com (Jane Ellis) writes: > (long description of bad Tuss experience deleted) >i'm wondering to myself how much this whole reaction was related to >simply set and setting. My take on this one is that there is the potential for some significant adverse effect in some people. My own experience (posted a week or so ago) included what I interpret as a fairly severe histamine reaction. It might be interesting to find out if Jane Ellis has other problems with histamines - for instance hay fever. A friend of mine who happens to be a nurse is the one who first proposed this theory. I would very much appreciate anything anyone here has to offer in the way of more educated viewpoints on the subject. If it gets posted soon enough, I might even get to read it before I experiment with the combination of 540mg DM and 50mg Benadryl which my nurse friend suggested. In the meantime, it might be wise for any sufferers of hay fever to move very carefully with this stuff, in case there is a corelation. -- /^v^\ |There are no rehearsals - live like you mean it already. ( 0 0 ) | uuuu U uuuu | pearl@crl.com (this is more reliable) Pearlie was here | pearl@cyberden.sf.ca.us ============================================================================= Message-ID: <005302Z25011994@anon.penet.fi> Newsgroups: alt.drugs From: an45874@anon.penet.fi Date: Tue, 25 Jan 1994 00:45:56 UTC Subject: Dextromethorphan Experience [text deleted -cak] I've included a few references, Read and Learn. The products I took contained dextromethorphan as an exclusive active ingredient. I included the info in guaifenesin because you're likely to come across it in reading labels. Note what Merk has to say about its efficacy. Drug Interaction: One of the packages boldly warns about combining dextromethorphan and any MAO inhibitor. Pay attention to it. From _The Merk Manual_ 16th ed. [My comments/edits in brackets[]] Dextromethorphan: a cogener of the narcotic analgesic levorphanol, possesses no significant analgesic or sedative properties, does not repress respiration in usual doses, and is nonaddictive. No evidencs of tolerance has been found during long-term use. The average dosage for adults is 15 to 30 mg. t to 4 times/day. given as a tablet or syrup; for children 1 mg/kg/day is given in divided doses. Extremely high doses may depress respiration [I have no idea (and it didn't indicate) what 'extremely high' means]. [It acts to] inhibit or supress the cough reflex by depressing the medullary cough center or associated higher centers. Guaifenesin: is the most commonly used expectorant in OTC cough remedies. It has no serious side effects, but there is no clear evidence for its efficacy. From _Dorland's Pocket Medical Dictionary_ (23rd ed.): analgesic: ... an agent that relieves pain ... cogenor: congenor congenor: ... a chemical compound closely related to another in composition and exerting similar or antagonistic effects, or something derived from the same source of stock. dextromethorphan: a synthetic morphine derivative (C18H25NO) used as an antitussive (cough supressant) in the form of the hydrobromide salt. guaifenesin: the glyceryl ester of guaiacol (C10H14O4), used as an expectorant. levorphanol: a narcotic analgesic (C17H23NO). morphine: the principal and most active alkaloid of opium (C17H19NO2), its hydrochloride and sulfate salts are used as narcotic analgesics. narcotic: a drug that produces insensibility or stupor, especially an opioid. 8 teaspoons = 1 ounce approx. (For while you're standing there reading labels) Information taken from references is included without permission. ------------------------------------------------------------------------- To find out more about the anon service, send mail to help@anon.penet.fi. Due to the double-blind, any mail replies to this message will be anonymized, and an anonymous id will be allocated automatically. You have been warned. Please report any problems, inappropriate use etc. to admin@anon.penet.fi. ============================================================================= Newsgroups: alt.drugs From: ez029006@othello.ucdavis.edu (Jon ) Subject: Harpers Robo article Message-ID: Date: Thu, 3 Feb 1994 02:57:05 GMT The June 1993 Harper's magazine has a cool little article about robo-ing. I believe they got it from the Spring issue of Pills-a-go-go, whatever that is. The article is by Jim Hogshire, and it is pretty acurate. He tells of his adventures following drinking eight ounces of the magic elixir. I especially liked the part about being a reptile. So if you are at all interested in robo, go to the library and give it a read. --Jon ============================================================================= Date: Wed, 17 Nov 1993 14:45:30 +1000 From: Stuart McLean Subject: Re: Cough Medicine abuse Sender: Drug Abuse Education Information and Research Message-id: <01H5E8FWZG8I8ZE7R4@YMIR.Claremont.Edu> Another important aspect of dextromethorphan is that about one in ten people have an inherited deficiency in the enzyme which metabolises this drug (by O-demethylation). This proportion may be different for non-European ethnic groups. The consequence is that the effects of dextromethorphan are likely to be more intense and more prolonged in these individuals than in the rest of the population. Each individual's capacity to metabolise dextromethorphan can only be determined by chemical analysis. Ref. Schmid et al. Clin Pharmacol Ther 1985; 38(6): 618-624. ___________________________________________________________________ Stuart McLean Telephone (002) 202 199 School of Pharmacy Facsimile (002) 202 870 University of Tasmania International callers: GPO Box 252C, Hobart 7001 please use 61 02 in place of 002 Australia Email ============================================================================= AUTHOR: Schmid B; Bircher J; Preisig R; Kupfer A TITLE: Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. SOURCE: Clin Pharmacol Ther (DHR), 1985 Dec; 38 (6): 618-24 LANGUAGE: English COUNTRY PUB.: UNITED STATES ANNOUNCEMENT: 8603 PUB. TYPE: JOURNAL ARTICLE ABSTRACT: Dextromethorphan hydrobromide, 25 mg po, was given to 268 unrelated Swiss subjects to study urinary drug and metabolite profiles. Rates of O-demethylation yielding the main metabolite dextrorphan were expressed by the urinary dextromethorphan/dextrorphan metabolic ratio. We found a bimodal distribution of this parameter in our population study, which indicates that there are two phenotypes for dextromethorphan O-demethylation. The antimode at a metabolic ratio of 0.3 separated the poor metabolizer (PM; n = 23; prevalence of 9%) from extensive metabolizer (EM) phenotypes. Urinary output of dextrorphan was less than 6% of the dose in all PMs and was 50% in the 245 EMs. Pedigree analysis of 14 family studies revealed an autosomal- recessive transmission of deficient dextromethorphan O- demethylation. In these families, 37 heterozygous genotypes could be identified; however, through use of the urinary drug and metabolite analysis it was not possible to identify the heterozygous genotypes within the EM phenotype group. Co- segregation of dextromethorphan O-demethylation with debrisoquin 4-hydroxylation was also studied. Complete concordance of the two phenotypic assignments was obtained, with a Spearman rank correlation coefficient of rs = 0.78 (n = 62; P less than 0.0001) for dextromethorphan and debrisoquin metabolic ratios. Presumably the two drug oxidation polymorphisms are under the same genetic control. Thus the innocuousness and ubiquitous availability of dextromethorphan render it attractive for worldwide pharmacogenetic investigations in man. MESH HEADINGS: Dextromethorphan--urine (UR)/metabolism (*ME); Dextrorphan-- urine (*UR); Levorphanol--analogs & derivatives (*AA); Morphinans--urine (*UR); Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Hydroxylation; Middle Age; Pedigree; Phenotype; Female; Human; Male; Support, Non- U.S. Gov't CHEMICAL SUBS: 0 (Morphinans); 125-71-3 (Dextromethorphan); 125-73-5 (Dextrorphan); 77-07-6 (Levorphanol) STANDARD NO.: 0009-9236